Scientists Built a Functional Computer With Human Brain Tissue

12 December 2023 B yMICHELLE STARR
Organoid Computer
One of the organoids in the experiment. (Cai et al., Nat. Electron., 2023)

There is no computer even remotely as powerful and complex as the human brain. The lumps of tissue ensconced in our skulls can process information at quantities and speeds that computing technology can barely touch. Key to the brain’s success is the neuron’s efficiency in serving as both a processor and memory device, in contrast to the physically separated units in most modern computing devices.

 There have been many attempts to make computing more brain-like, but a new effort takes it all a step further – by integrating real, actual, human brain tissue with electronics.
 It’s called Brainoware, and it works. A team led by engineer Feng Guo of Indiana University Bloomington fed it tasks like speech recognition and nonlinear equation prediction.
 It was slightly less accurate than a pure hardware computer running on artificial intelligence, but the research demonstrates an important first step in a new kind of computer architecture.
 However, while Guo and his colleagues followed the ethics guidelines in the development of Brainoware, several researchers from Johns Hopkins University note in a related Nature Electronics commentary the importance of keeping ethical considerations in mind while expanding this technology further.
 Lena Smirnova, Brian Caffo, and Erik C. Johnson, who weren’t involved with the study, caution, “As the sophistication of these organoid systems increases, it is critical for the community to examine the myriad of neuroethical issues that surround biocomputing systems incorporating human neural tissue.”

A diagram illustrating how Brainoware works. (Cai et al., Nat. Electron., 2023)

The human brain is kind of jaw-droppingly amazing. It contains an estimated 86 billion neurons, on average, and up to a quadrillion synapses. Each neuron is connected to up to 10,000 other neurons, constantly firing and communicating with each other. To date, our best effort to simulate the activity of the brain in an artificial system barely scratched the surface.

 In 2013, Riken’s K Computer – then one of the most powerful supercomputers in the world – made an attempt to mimic the brain. With 82,944 processors and a petabyte of main memory, it took 40 minutes to simulate one second of the activity of 1.73 billion neurons connected by 10.4 trillion synapses – around just one to two percent of the brain.
 In recent years, scientists and engineers have been trying to approach the capabilities of the brain by designing hardware and algorithms that mimic its structure and the way it works. Known as neuromorphic computing, it is improving but it’s energy-intensive, and training artificial neural networks is time-consuming.

Left to right, top: Human brain organoids at 7 days, 14 days, 28 days, and several months; Bottom, left to right: 1 month, 2 months, 3 months. (Cai et al., Nat. Electron., 2023)

Guo and his colleagues sought a different approach using real human brain tissue grown in a lab. Human pluripotent stem cells were coaxed into developing into different types of brain cells that organized into three-dimensional mini-brains called organoids, complete with connections and structures.

These aren’t true brains, but simply arrangements of tissue without anything resembling thought, emotion, or consciousness. They’re useful for studying how the brain develops and works, without poking around in an actual human.

 Brainoware consists of brain organoids connected to an array of high-density microelectrodes, using a type of artificial neural network known as reservoir computing. Electrical stimulation transports information into the organoid, the reservoir wherein that information is processed before Brainoware spits out its calculations in the form of neural activity.
 Normal computer hardware is used for the input and output layers. These layers had to be trained to function with the organoid, with the output layer reading the neural data and making classifications or predictions based on the input.
 To demonstrate the system, the researchers gave Brainoware 240 audio clips from eight male speakers making Japanese vowel sounds, and asked it to identify one specific individual’s voice.
 They started with a naive organoid; after training for just two days, Brainoware was able to identify the speaker with 78 percent accuracy.

An example of one of the organoids, and its scanned neural activity. (Cai et al., Nat. Electron., 2023)

They also asked Brainoware to predict a Hénon map, a dynamical system that exhibits chaotic behavior. They left it unsupervised to learn for four days – each day representing a training epoch – and found it was able to predict the map with better accuracy than an artificial neural network without a long short-term memory unit.

Brainoware was slightly less accurate than artificial neural networks with a long short-term memory unit – but those networks had each undergone 50 training epochs. Brainoware achieved close to the same results in less than 10 percent of the training time.

 “Due to the high plasticity and adaptability of organoids, Brainoware has the flexibility to change and reorganize in response to electrical stimulation, highlighting its ability for adaptive reservoir computing,” the researchers write.
 There are still significant limitations, including the issue of keeping the organoids alive and healthy, and the peripheral equipment power consumption levels. But, bearing ethical considerations in mind, Brainoware has implications not just for computing, but understanding the mysteries of the human brain.
 “It may be decades before general biocomputing systems can be created, but this research is likely to generate foundational insights into the mechanisms of learning, neural development and the cognitive implications of neurodegenerative diseases,” Smirnova, Caffo, and Johnson write.
 “It could also help to develop preclinical models of cognitive impairment to test new therapeutics.”

The research has been published in Nature Electronics.

https://www.sciencealert.com/scientists-built-a-functional-computer-with-human-brain-tissue